Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 5/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970294 | 0.83 | MEN1 (0.44) | MAPTKMT2ANPSR1ALDH1A1HPGD | |
| SCHEMBL1516027 | 0.83 | MMP8 (0.53) | MAPTKMT2AKDM4EMEN1LMNA | |
| SCHEMBL2695334 | 0.81 | GAA (0.46) | MAPTKMT2ANPSR1ALDH1A1HPGD | |
| SCHEMBL11770256 | 0.81 | ESR1 (0.49) | MAPTKMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL27971666 | 0.80 | MAPT (0.47) | MAPTPOLBPKMKMT2ANPSR1 | |
| SCHEMBL2554850 | 0.80 | MAPT (0.47) | MAPTKMT2ANPSR1ALDH1A1HPGD | |
| SCHEMBL3232287 | 0.80 | CA12 (0.45) | MAPTPOLBNPSR1ALDH1A1HPGD | |
| SCHEMBL6154370 | 0.79 | MMP8 (0.51) | NAMPTCDC7DBF4MAPTPOLB | |
| SCHEMBL6669586 | 0.79 | ALOX15 (0.47) | MAPTPOLBKMT2ANPSR1ALDH1A1 | |
| SCHEMBL1970366 | 0.79 | MEN1 (0.46) | POLBKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222172-A1 | Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives | SANOFI (FR) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222172-A1 | Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives | GSK3A, GSK3B, CDK5 | NAMPT 1851/4885CDC7 703/4885DBF4 4706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.