Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 5/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669586 | 0.87 | ALOX15 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1970294 | 0.85 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11770256 | 0.83 | ESR1 (0.49) | KMT2ATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27971666 | 0.82 | MAPT (0.47) | MEN1KMT2ATDP1MAPK1ALDH1A1 | |
| SCHEMBL3232287 | 0.82 | CA12 (0.45) | TDP1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2554850 | 0.82 | MAPT (0.47) | MEN1KMT2ATDP1SMN1; SMN2MAPK1 | |
| SCHEMBL1516027 | 0.81 | MMP8 (0.53) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10719216 | 0.80 | NQO1 (0.52) | MEN1KMT2ATDP1NQO1PARP10 | |
| SCHEMBL6971962 | 0.79 | ALDH1A1 (0.45) | MEN1KMT2ASMN1; SMN2MAPK1AKR1C3 | |
| SCHEMBL6141592 | 0.79 | NAMPT (0.42) | MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8029696-B2 | Fused naphthalenes | MERCK PATENT GMBH (DE) | 2011-10-04 | — | — | US | disclosed |
| EP-2044172-B1 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2011-06-22 | — | — | EP | disclosed |
| US-20100059711-A1 | FUSED NAPHTHALENES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-03-11 | — | — | US | disclosed |
| EP-2044172-A1 | FUSED NAPHTHALENES | Merck Patent GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008012180-A9 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008012180-A1 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100059711-A1 | FUSED NAPHTHALENES | CCNE2, CCNE1, F12 | MEN1 551/4885KMT2A 3379/4885TDP1 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.