Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142181 | 0.81 | PLAU (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL22324148 | 0.73 | ALDH1A1 (0.53) | ADRA1AHTTCYP1A2CYP2C19CASP6 | |
| SCHEMBL6142541 | 0.70 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL1163802 | 0.69 | HTT (0.53) | HTTCYP1A2CYP2C19CASP6ALDH1A1 | |
| SCHEMBL28370443 | 0.69 | CASP6 (0.62) | HTTCYP1A2CYP2C19CASP6ALDH1A1 | |
| SCHEMBL30540041 | 0.69 | HTT (0.53) | HTTCYP1A2CYP2C19CASP6ALDH1A1 | |
| SCHEMBL8123144 | 0.69 | ALDH1A1 (0.53) | ADRA1AHTTCYP1A2CYP2C19CASP6 | |
| SCHEMBL3587363 | 0.69 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19CASP6ALDH1A1 | |
| SCHEMBL30456422 | 0.69 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19CASP6ALDH1A1 | |
| SCHEMBL150476 | 0.69 | NPC1 (0.65) | HTTCYP1A2CYP2C19CASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944604-B1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2005-01-12 | — | — | EP | claimed |