Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142571 | 0.81 | ADRA2A (0.45) | PLAUMAPTMEN1KMT2AATM | |
| SCHEMBL31186675 | 0.75 | ALDH1A1 (0.61) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL8404544 | 0.75 | ALDH1A1 (0.61) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL7032103 | 0.75 | ALDH1A1 (0.41) | PLAUMAPTMEN1KMT2AATM | |
| SCHEMBL21593663 | 0.75 | NPC1 (0.43) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL30344129 | 0.73 | PARP1 (0.50) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL3063225 | 0.73 | CASP6 (0.58) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL5542743 | 0.73 | ALDH1A1 (0.53) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL6142388 | 0.70 | LMNA (0.49) | PLAUMAPTMEN1KMT2ANPC1 | |
| SCHEMBL23596020 | 0.69 | ALDH1A1 (0.53) | MAPTMEN1KMT2AATMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944604-B1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2005-01-12 | — | — | EP | claimed |