Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142865 | 0.87 | S1PR5 (0.41) | HTR6BCHES1PR5HRH3NPY1R | |
| SCHEMBL6143807 | 0.81 | GPR119 (0.49) | HRH3GPR119 | |
| SCHEMBL6143897 | 0.81 | GPR119 (0.47) | HRH3GPR119MAPT | |
| SCHEMBL6143471 | 0.79 | GPR119 (0.50) | GPR119 | |
| SCHEMBL6109296 | 0.77 | HRH3 (0.62) | HRH3KMT2AMEN1GAAMAPT | |
| Hydrochloric Acid SCHEMBL6109294 | 0.76 | HRH3 (0.61) | HRH3KMT2AMEN1GAAMAPT | |
| SCHEMBL2885921 | 0.72 | NOTUM (0.47) | BCHEUCHL1KMT2AGPR119MEN1 | |
| SCHEMBL31013904 | 0.70 | NOTUM (0.46) | HTR6BCHEUCHL1GPR119 | |
| SCHEMBL2885604 | 0.70 | UCHL1 (0.47) | BCHEUCHL1KMT2AMEN1 | |
| SCHEMBL20571008 | 0.70 | UCHL1 (0.61) | BCHEUCHL1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |