Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 8/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142844 | 0.87 | HTR6 (0.43) | S1PR5NPY1RGPR119KMT2AMEN1 | |
| SCHEMBL6152212 | 0.81 | TSHR (0.45) | S1PR5NPY1RKMT2AMEN1LMNA | |
| SCHEMBL6143807 | 0.81 | GPR119 (0.49) | GPR119HRH3 | |
| SCHEMBL6143897 | 0.81 | GPR119 (0.47) | GPR119MAPTHRH3 | |
| SCHEMBL6110825 | 0.78 | HRH3 (0.61) | KMT2AMEN1GAAMAPTHRH3 | |
| SCHEMBL6143471 | 0.76 | GPR119 (0.50) | GPR119 | |
| SCHEMBL31139409 | 0.74 | MEN1 (0.46) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL6108617 | 0.70 | P2RX1 (0.50) | KMT2AMEN1MAPTNPSR1HSD11B1 | |
| SCHEMBL16593635 | 0.70 | NOTUM (0.41) | KMT2AMEN1 | |
| SCHEMBL3500072 | 0.69 | MEN1 (0.40) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |