Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143807 | 0.93 | GPR119 (0.49) | GPR119ITGB3ITGA2BHRH3MPO | |
| SCHEMBL6143471 | 0.89 | GPR119 (0.50) | GPR119ITGB3ITGA2B | |
| SCHEMBL6142844 | 0.81 | HTR6 (0.43) | GPR119HRH3MAPT | |
| SCHEMBL6142865 | 0.81 | S1PR5 (0.41) | GPR119HRH3MAPT | |
| SCHEMBL6143538 | 0.80 | HRH3 (0.65) | HRH3MAPTTSHR | |
| SCHEMBL6111308 | 0.78 | HRH3 (0.63) | HRH3 | |
| SCHEMBL15898288 | 0.76 | CHRM4 (0.46) | GPR119HRH3MAPTTSHR | |
| SCHEMBL6143574 | 0.75 | GPR119 (0.44) | GPR119ITGB3ITGA2BHRH3 | |
| SCHEMBL30802841 | 0.74 | HSD17B10 (0.54) | MAPTTSHR | |
| SCHEMBL1734457 | 0.74 | HSD17B10 (0.54) | MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |