Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143807 | 0.96 | GPR119 (0.49) | GPR119ITGB3ITGA2B | |
| SCHEMBL6143897 | 0.89 | GPR119 (0.47) | GPR119ITGB3ITGA2B | |
| SCHEMBL6143574 | 0.82 | GPR119 (0.44) | GPR119ITGB3ITGA2B | |
| SCHEMBL26863132 | 0.79 | GPR119 (0.55) | GPR119ITGB3ITGA2B | |
| SCHEMBL6142844 | 0.79 | HTR6 (0.43) | GPR119 | |
| SCHEMBL5637515 | 0.78 | GPR119 (0.48) | GPR119 | |
| SCHEMBL6109975 | 0.77 | HRH3 (0.58) | — | |
| SCHEMBL6142865 | 0.76 | S1PR5 (0.41) | GPR119 | |
| SCHEMBL6109527 | 0.76 | HRH3 (0.51) | — | |
| SCHEMBL3656194 | 0.75 | HSD17B10 (0.50) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |