Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.84 |
| ▸ | LMNA | P02545 | 7/20 | 0.84 |
| ▸ | CTSV | O60911 | 5/20 | 0.84 |
| ▸ | CTSL | P07711 | 5/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.84 |
| ▸ | TP53 | P04637 | 2/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.84 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.84 |
| ▸ | TUBB | P07437 | 1/20 | 0.84 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.84 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.84 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.84 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.84 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.84 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.84 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.84 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.84 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.84 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367268 | 0.92 | HPGD (1.00) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL29411863 | 0.92 | HPGD (1.00) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL30935678 | 0.82 | HPGD (1.00) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL6534180 | 0.82 | HPGD (1.00) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL311524 | 0.82 | CTSV (0.75) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL25911115 | 0.82 | TUBB4A (0.69) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL2630603 | 0.79 | HPGD (0.76) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL6001723 | 0.79 | CTSV (0.75) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL29411879 | 0.79 | CTSV (1.00) | HPGDLMNACTSVCTSLKDM4E | |
| SCHEMBL26847067 | 0.79 | CTSV (0.77) | HPGDLMNACTSVCTSLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1596864-A2 | FLAVONE ACETIC ACID ANALOGS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050171138-A1 | Flavone acetic acid analogs and methods of use thereof | LEE KUO-HSIUNG (US) | 2005-08-04 | — | — | US | disclosed |
| US-6916831-B2 | Flavone acetic acid analogs and methods of use thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-07-12 | — | — | US | disclosed |
| WO-2004075858-A2 | FLAVONE ACETIC ACID ANALOGS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2004-09-10 | — | — | WO | disclosed |
| US-20040167151-A1 | Flavone acetic acid analogs and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171138-A1 | Flavone acetic acid analogs and methods of use thereof | HAO1, HAO2, AOX1 | HPGD 1151/4885LMNA 4246/4885CTSV 2499/4885 |
| US-20040167151-A1 | Flavone acetic acid analogs and methods of use thereof | HAO1, HAO2, AOX1 | HPGD 787/4885LMNA 3923/4885CTSV 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.