Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227447 | 0.81 | ALDH1A1 (0.56) | HPGDKDM4EALDH1A1HSD17B10MAOA | |
| SCHEMBL1906715 | 0.76 | POLB (0.55) | HPGDSMN1; SMN2KDM4EALDH1A1HSD17B10 | |
| Acetic Acid SCHEMBL27642498 | 0.75 | HPGD (0.59) | HPGDSMN1; SMN2KDM4EALDH1A1NPSR1 | |
| SCHEMBL3373253 | 0.75 | P2RX4 (0.47) | HPGDSMN1; SMN2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9386193 | 0.73 | HPGD (1.00) | HPGDSMN1; SMN2KDM4EALDH1A1NPSR1 | |
| SCHEMBL25327891 | 0.72 | HPGD (0.55) | HPGDSMN1; SMN2KDM4EALDH1A1NPSR1 | |
| SCHEMBL28852105 | 0.70 | HPGD (0.65) | HPGDSMN1; SMN2KDM4EALDH1A1NPSR1 | |
| SCHEMBL5199685 | 0.69 | ALDH1A1 (0.46) | HPGDSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL27620887 | 0.69 | EGFR (0.45) | HPGDKDM4EALDH1A1POLBAGTR1 | |
| SCHEMBL8431590 | 0.69 | PARP1 (0.44) | HPGDKDM4EALDH1A1NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1596864-A2 | FLAVONE ACETIC ACID ANALOGS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050171138-A1 | Flavone acetic acid analogs and methods of use thereof | LEE KUO-HSIUNG (US) | 2005-08-04 | — | — | US | disclosed |
| US-6916831-B2 | Flavone acetic acid analogs and methods of use thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-07-12 | — | — | US | disclosed |
| WO-2004075858-A2 | FLAVONE ACETIC ACID ANALOGS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2004-09-10 | — | — | WO | disclosed |
| US-20040167151-A1 | Flavone acetic acid analogs and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171138-A1 | Flavone acetic acid analogs and methods of use thereof | HAO1, HAO2, AOX1 | HPGD 1151/4885SMN1; SMN2 3753/4885KDM4E 2044/4885 |
| US-20040167151-A1 | Flavone acetic acid analogs and methods of use thereof | HAO1, HAO2, AOX1 | HPGD 787/4885SMN1; SMN2 3869/4885KDM4E 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.