Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143471 | 0.82 | GPR119 (0.50) | GPR119ITGB3ITGA2B | |
| SCHEMBL6109275 | 0.81 | HRH3 (0.56) | HRH3 | |
| SCHEMBL6143807 | 0.80 | GPR119 (0.49) | GPR119ITGB3ITGA2BHRH3 | |
| SCHEMBL6143554 | 0.77 | CA12 (0.38) | GPR119CA12CA1CA2CA9 | |
| SCHEMBL6143897 | 0.75 | GPR119 (0.47) | GPR119ITGB3ITGA2BHRH3 | |
| SCHEMBL15358145 | 0.74 | TDP1 (0.46) | HRH3CA12CA1CA2CA9 | |
| SCHEMBL6632127 | 0.72 | ITGB3 (0.61) | ITGB3ITGA2BHRH3 | |
| SCHEMBL1009654 | 0.71 | EPHX1 (0.47) | CTSS | |
| SCHEMBL2386412 | 0.71 | EPHX1 (0.47) | CTSS | |
| SCHEMBL6143785 | 0.69 | GPR119 (0.39) | GPR119ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585731-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004026837-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATON AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |