SCHEMBL6152570

SCHEMBL6152570

COc1c(C)cc(N)c(C)c1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
CYP3A4 P08684 3/20 0.39
TSHR P16473 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
MAPK1 P28482 1/20 0.39
TP53 P04637 1/20 0.39
DHFR P00374 2/20 0.37
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36
TUBA1C Q9BQE3 1/20 0.36
TUBB6 Q9BUF5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27773010 0.84 CYP3A4 (0.40) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL3008135 0.84 IMPDH2 (0.41) ALDH1A1CYP3A4TSHRMAPK1DHFR
Hydrochloric Acid SCHEMBL8946544 0.82 IMPDH2 (0.40) ALDH1A1CYP3A4TSHRMAPK1DHFR
SCHEMBL19573968 0.80 ACHE (0.40) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL14511738 0.80 ACHE (0.43) ALDH1A1CYP3A4TDP1TUBB4ATUBB
SCHEMBL29568447 0.79 CYP3A4 (0.40) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL3010210 0.79 CYP3A4 (0.40) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL442754 0.77 ALDH1A1 (0.39) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL30776799 0.77 ALDH1A1 (0.39) ALDH1A1CYP3A4TSHRTDP1MAPK1
SCHEMBL5266756 0.77 ALDH1A1 (0.38) ALDH1A1CYP3A4TSHRTDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1301163-B1 OXIDATIVE HAIR COLOURING AGENTS CONTAINING AT LEAST ONE DISUBSTITUITED 2,4-DIAMINO PHENYL ETHER AS A COUPLING COMPONENT HENKEL KGAA (DE) 2005-01-26 EP disclosed
EP-1301163-A1 OXIDISED HAIR COLOURING AGENTS CONTAINING AT LEAST ONE DISUBSTITUITED 2.4-DIAMINO PHENYL ETHER AS A COUPLING COMPONENT Henkel Kommanditgesellschaft auf Aktien (DE) 2003-04-16 EP disclosed
WO-2002005767-A1 OXIDISED HAIR COLOURING AGENTS CONTAINING AT LEAST ONE DISUBSTITUITED 2.4-DIAMINO PHENYL ETHER AS A COUPLING COMPONENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-01-24 WO disclosed