Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 8/20 | 0.68 |
| ▸ | NOS1 | P29475 | 8/20 | 0.68 |
| ▸ | NOS2 | P35228 | 6/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152762 | 0.83 | NOS3 (0.46) | NOS3NOS1NOS2CCNT1CDK9 | |
| SCHEMBL6153077 | 0.82 | NOS3 (0.46) | NOS3NOS1NOS2KDM4E | |
| SCHEMBL6583124 | 0.82 | NOS1 (0.48) | NOS3NOS1NOS2HTR7HTR1B | |
| SCHEMBL5838088 | 0.81 | NOS1 (1.00) | NOS3NOS1NOS2 | |
| SCHEMBL5833803 | 0.81 | NOS3 (0.67) | NOS3NOS1NOS2CCNT1CDK9 | |
| SCHEMBL6152396 | 0.80 | NOS3 (0.43) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL6152661 | 0.80 | NOS3 (0.71) | NOS3NOS1NOS2CCNT1CDK9 | |
| SCHEMBL6155624 | 0.79 | NOS3 (0.43) | NOS3NOS1NOS2 | |
| SCHEMBL7450787 | 0.78 | NOS3 (0.71) | NOS3NOS1NOS2HTR7HTR1B | |
| SCHEMBL6152641 | 0.78 | NOS3 (0.38) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084109-B1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2005-01-26 | — | — | EP | disclosed |