Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | DUT | P33316 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152424 | 0.77 | KIF11 (0.45) | KIF11DUTKCNN4MIFCHRM3 | |
| SCHEMBL6153063 | 0.75 | NPSR1 (0.35) | KIF11DUT | |
| SCHEMBL3136435 | 0.73 | KIF11 (0.61) | KIF11DUTKCNN4MIF | |
| SCHEMBL3111880 | 0.72 | KIF11 (0.59) | KIF11DUTKCNN4MIF | |
| SCHEMBL12264133 | 0.72 | KIF11 (0.68) | KIF11DUTKCNN4 | |
| SCHEMBL7178486 | 0.70 | LTA4H (0.40) | — | |
| SCHEMBL17980741 | 0.70 | KIF11 (0.52) | KIF11DUTKCNN4MIF | |
| SCHEMBL1809571 | 0.69 | KIF11 (0.63) | KIF11DUTKCNN4MIF | |
| SCHEMBL28640563 | 0.68 | KIF11 (0.49) | KIF11DUTKCNN4MIFCHRM3 | |
| SCHEMBL12264131 | 0.68 | KIF11 (0.74) | KIF11DUTKCNN4MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| US-6653313-B2 | For treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders | WARNER-LAMBERT COMPANY LLC | 2003-11-25 | — | — | US | disclosed |
| US-20020161006-A1 | 1,4-dihydropyridine compounds as bradykinin antagonists | KAWAMURA MITSUHIRO (US) | 2002-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161006-A1 | 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, HRH4 | KIF11 3211/4885DUT 2004/4885KCNN4 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.