Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153323 | 0.91 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1KDM4EMCHR1GAA | |
| SCHEMBL6154012 | 0.87 | OPRK1 (0.55) | SIGMAR1KDM4EOPRK1MCHR1GAA | |
| SCHEMBL6153502 | 0.86 | OPRK1 (0.59) | SIGMAR1ALDH1A1KDM4EOPRK1MCHR1 | |
| SCHEMBL6157012 | 0.86 | OPRK1 (0.56) | SIGMAR1KDM4EOPRK1MCHR1GAA | |
| SCHEMBL6156960 | 0.85 | OPRK1 (0.55) | SIGMAR1ALDH1A1KDM4EOPRK1MCHR1 | |
| SCHEMBL6153245 | 0.85 | GAA (0.65) | SIGMAR1KDM4EOPRK1MCHR1GAA | |
| SCHEMBL6153280 | 0.84 | OPRK1 (0.55) | SIGMAR1ALDH1A1KDM4EOPRK1GAA | |
| SCHEMBL6154073 | 0.82 | DRD4 (0.58) | SIGMAR1OPRK1TSHRDRD2DRD4 | |
| SCHEMBL6156084 | 0.82 | DRD4 (0.68) | OPRK1DRD2DRD4DRD3CYP1A2 | |
| SCHEMBL6153689 | 0.82 | MAPK1 (0.55) | SIGMAR1KDM4EOPRK1MCHR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | SIGMAR1 695/4885ALDH1A1 2454/4885KDM4E 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.