Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | PGD | P52209 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414980 | 0.88 | LMNA (0.60) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL10712935 | 0.87 | LMNA (0.55) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL4928056 | 0.86 | LMNA (0.58) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL13229795 | 0.86 | LMNA (0.58) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL4923280 | 0.86 | LMNA (0.58) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL4923275 | 0.86 | LMNA (0.58) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL27535340 | 0.84 | LMNA (0.56) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL31571128 | 0.84 | LMNA (0.56) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL6036839 | 0.84 | LMNA (0.51) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 | |
| SCHEMBL5175797 | 0.84 | LMNA (0.51) | LMNASMN1; SMN2ALOX15MMP12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014140006-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF 3-HYDROXY-GLUTARIC ACID MONOESTERS AND USE THEREOF | SANDOZ AG (CH) | 2014-09-18 | — | — | WO | disclosed |
| US-20050119341-A1 | 3-substituted oxyglutaric diester compound, optically active 3-substituted oxyglutaric monoester compound, and processes for producing these | UBE INDUSTRIES, LTD. (JP) | 2005-06-02 | — | — | US | disclosed |
| EP-1500642-A1 | 3-SUBSTITUTED OXYGLUTARIC DIESTER COMPOUND, OPTICALLY ACTIVE 3-SUBSTITUTED OXYGLUTARIC MONOESTER COMPOUND, AND PROCESSES FOR PRODUCING THESE | Ube Industries, Ltd. (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-20020127577-A1 | Bioactive sensors | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-09-12 | — | — | US | disclosed |
| EP-0168480-A4 | PROCESS FOR PREPARING OPTICALLY-ACTIVE 4-AMINO-3-HYDROXYBUTYRIC ACID. | WISCONSIN ALUMNI RES FOUND (US) | 1987-10-08 | — | — | EP | disclosed |
| US-4584270-A | ENZYME CLEAVAGE OF ESTER GROUPING OF 3-HYDROXYGLUTARIC ACID DIESTER, FOLLOWED BY CHEMICAL CONVERSION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1986-04-22 | — | — | US | disclosed |
| EP-0168480-A1 | PROCESS FOR PREPARING OPTICALLY-ACTIVE 4-AMINO-3-HYDROXYBUTYRIC ACID | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1986-01-22 | — | — | EP | disclosed |
| WO-1985003307-A1 | PROCESS FOR PREPARING OPTICALLY-ACTIVE 4-AMINO-3-HYDROXYBUTYRIC ACID | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1985-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119341-A1 | 3-substituted oxyglutaric diester compound, optically active 3-substituted oxyglutaric monoester compound, and processes for producing these | OGDH, GLUL, ADSL | LMNA 4022/4885SMN1; SMN2 4749/4885ALOX15 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.