Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850635 | 0.76 | MEN1 (0.51) | MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL1555150 | 0.76 | ERBB2 (0.41) | SMN1; SMN2ALDH1A1NOTUM | |
| SCHEMBL3848746 | 0.76 | ERBB2 (0.41) | NOTUMKDM4E | |
| SCHEMBL6155891 | 0.76 | PDE3B (0.39) | MAPTSMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL518672 | 0.75 | ALOX15 (0.48) | MAPTSMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL2148744 | 0.73 | LMNA (0.40) | MAPTNOTUM | |
| SCHEMBL27735723 | 0.71 | NPSR1 (0.35) | SMN1; SMN2ALDH1A1TSHRPTGDR2KDM4E | |
| SCHEMBL3846701 | 0.71 | NOTUM (0.39) | MAPTSMN1; SMN2ALDH1A1TSHRNOTUM | |
| SCHEMBL27844934 | 0.71 | ERBB2 (0.41) | NOTUM | |
| SCHEMBL4317166 | 0.69 | ABCC8 (0.46) | MAPTSMN1; SMN2ALDH1A1NOTUMAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553985-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | The Trustees of The University of Pennsylvania (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004032975-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-22 | — | — | WO | disclosed |