SCHEMBL518672

SCHEMBL518672

Brc1c[nH]nc1-c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.48
ALDH1A1 P00352 5/20 0.42
MAPT P10636 3/20 0.42
GFER P55789 1/20 0.42
DCLK1 O15075 1/20 0.42
PRKD3 O94806 1/20 0.42
MAP4K4 O95819 1/20 0.42
CHEK2 O96017 1/20 0.42
CSF1R P07333 1/20 0.42
FER P16591 1/20 0.42
CDK2 P24941 1/20 0.42
MARK3 P27448 1/20 0.42
FLT4 P35916 1/20 0.42
FLT3 P36888 1/20 0.42
MAPK9 P45984 1/20 0.42
CSNK1D P48730 1/20 0.42
CLK2 P49760 1/20 0.42
CSNK2A1 P68400 1/20 0.42
CSNK1G2 P78368 1/20 0.42
MAP4K2 Q12851 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29484273 0.87 GP6 (0.42) ALOX15ALDH1A1MAPTGFERDCLK1
SCHEMBL17900083 0.87 GP6 (0.42) ALOX15ALDH1A1MAPTGFERDCLK1
SCHEMBL2148744 0.81 LMNA (0.40) MAPTCDK2MAPK9IDO1MAPK10
SCHEMBL6155891 0.79 PDE3B (0.39) ALOX15ALDH1A1MAPTKDM4EGAA
SCHEMBL1555150 0.79 ERBB2 (0.41) ALDH1A1PRKD3MAP4K4MAPK9CSNK1D
SCHEMBL3848746 0.79 ERBB2 (0.41) MKNK2KDM4EGAAALPLNPSR1
SCHEMBL2122515 0.79 CYP2A6 (0.48) ALOX15ALDH1A1MAPTKDM4EHPGD
SCHEMBL4305212 0.78 ROCK2 (0.56) MAPTCHEK2CSF1RCDK2MARK3
SCHEMBL26110065 0.77 IDO1 (0.44) ALDH1A1GFERKDM4EGAAIDO1
SCHEMBL218119 0.77 ALOX15 (0.52) ALOX15ALDH1A1MAPTGFERKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1063440-C Process for the desulfurization and the desalting of fossil fuels RHONE ROULENC AGROCHIMIE CORP (FR) 2001-03-21 CN claimed
CN-1079735-A Arylpyrazole mycocide ENERGY BIOSYSTEMS CORP (FR) 1993-12-22 CN claimed
US-20250236608-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2025-07-24 US disclosed
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 EP disclosed
EP-4504719-A1 EGFR INHIBITORS Blueprint Medicines Corporation (US) 2025-02-12 EP disclosed
CN-119325471-A EGFR inhibitors 缆图药品公司 2025-01-17 CN disclosed
CN-113166140-B CDK8/19 inhibitors 拜奥卡德联合股份公司 2024-06-14 CN disclosed
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. 2024-05-16 US disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 WO disclosed
US-11840531-B2 CDK8/19 inhibitors JOINT STOCK COMPANY "BIOCAD" (RU) 2023-12-12 US disclosed
WO-2023196283-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION (US) 2023-10-12 WO disclosed
US-5663119-A FOR USE IN AGRICULTURE RHONE-POULENC AGROCHIMIE (FR) 1997-09-02 US disclosed
CN-1131151-A Method for preparation of 3-phenyl pyrazole derivant RHONE POULENC AGROCHIMIE (FR) 1996-09-18 CN disclosed
US-5523280-A TREATING PLANT DISEASES RHONE-POULENC AGROCHIMIE (FR) 1996-06-04 US disclosed
EP-0638070-A1 FUNGICIDAL ARYLPYRAZOLES RHONE-POULENC AGROCHIMIE (FR) 1995-02-15 EP disclosed
CN-1079735-A Arylpyrazole mycocide ENERGY BIOSYSTEMS CORP (FR) 1993-12-22 CN disclosed
WO-1993022287-A1 FUNGICIDAL ARYLPYRAZOLES RHONE POULENC AGROCHIMIE (FR) 1993-11-11 WO disclosed
EP-0538156-A1 Fungicidal phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1993-04-21 EP disclosed
CN-1071162-A Novel phenylpyrazole fungicides RHONE POULENC AGROCHIMIE (FR) 1993-04-21 CN disclosed
US-4072498-A HERBICIDES THE UPJOHN COMPANY (US) 1978-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840531-B2 CDK8/19 inhibitors CDK8, CDK9, CDK18 ALOX15 3601/4885ALDH1A1 3487/4885MAPT 1595/4885
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS CKS1B, CKS2, MARK1 ALOX15 3260/4885ALDH1A1 1687/4885MAPT 768/4885
US-20250236608-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 ALOX15 4747/4885ALDH1A1 2147/4885MAPT 2806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.