Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848746 | 0.80 | ERBB2 (0.41) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1555150 | 0.80 | ERBB2 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL518672 | 0.79 | ALOX15 (0.48) | ALDH1A1CYP3A4ALOX15MAPK1MAPT | |
| SCHEMBL28111318 | 0.79 | CYP3A4 (0.42) | PDE3BPDE3APDE5APDE1APDE1B | |
| SCHEMBL2148744 | 0.78 | LMNA (0.40) | PDE3BPDE3APDE1APDE1BPDE1C | |
| SCHEMBL3850635 | 0.77 | MEN1 (0.51) | PDE3BPDE3APDE1APDE1BPDE1C | |
| SCHEMBL3850689 | 0.77 | NISCH (0.39) | ALDH1A1LMNA | |
| SCHEMBL10775547 | 0.76 | ALDH1A1 (0.39) | PDE3BPDE3APDE5APDE1APDE1B | |
| SCHEMBL27844934 | 0.76 | ERBB2 (0.41) | CA12CA1CA2CA9CHEK1 | |
| SCHEMBL6153844 | 0.76 | MAPT (0.41) | ALDH1A1ALOX15MAPTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553985-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | The Trustees of The University of Pennsylvania (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004032975-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-22 | — | — | WO | disclosed |