Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10089793 | 0.95 | HSD11B1 (0.40) | HSD11B1SLC40A1PKLREDNRBEDNRA | |
| SCHEMBL618696 | 0.78 | GAA (0.41) | HSD11B1PKLRPKMMAPTKDM4E | |
| SCHEMBL616832 | 0.77 | HSD11B1 (0.69) | HSD11B1SLC40A1PKLREDNRBEDNRA | |
| SCHEMBL617340 | 0.74 | LMNA (0.43) | PKLRPKMMAPTKDM4E | |
| SCHEMBL617902 | 0.73 | HSD11B1 (0.52) | HSD11B1SLC40A1PKLREDNRBEDNRA | |
| SCHEMBL616245 | 0.73 | CNR2 (0.38) | HSD11B1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10089789 | 0.72 | HSD11B1 (0.51) | HSD11B1SLC40A1PKLREDNRBEDNRA | |
| SCHEMBL10089753 | 0.71 | ALDH1A1 (0.61) | PKMMAPTMCOLN3KDM4E | |
| SCHEMBL617793 | 0.70 | TP53 (0.47) | PKMMAPT | |
| SCHEMBL10089740 | 0.69 | ALDH1A1 (0.47) | HSD11B1PKMHSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041207-A1 | Compound | STERIX LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20110009448-A1 | Compound | STERIX LIMITED | 2011-01-13 | — | — | US | disclosed |
| US-7786152-B2 | Compound | STERIX LIMITED (GB) | 2010-08-31 | — | — | US | disclosed |
| US-20080114042-A1 | Inhibiting 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD); use of sulfonamide-substituted N-heterocyclics including pyrroles, oxazoles, thiazoles, imidazoles and their fused analogs to treat diabetes, obesity, hypertension, arthritis, asthma, osteoporosis, breast cancer | STERIX LIMITED (GB) | 2008-05-15 | — | — | US | disclosed |
| US-7309715-B2 | Compound | STERIX LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| EP-1556040-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 | Sterix Limited (GB) | 2005-07-27 | — | — | EP | disclosed |
| US-20040143124-A1 | Compound | STERIX LIMITED (GB) | 2004-07-22 | — | — | US | disclosed |
| WO-2004037251-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 | STERIX LIMITED (GB) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114042-A1 | Inhibiting 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD); use of sulfonamide-substituted N-heterocyclics including pyrroles, oxazoles, thiazoles, imidazoles and their fused analogs to treat diabetes, obesity, hypertension, arthritis, asthma, osteoporosis, breast cancer | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885SLC40A1 4441/4885PKLR 978/4885 |
| US-20110009448-A1 | Compound | NR4A1, GPR6, PRMT6 | HSD11B1 331/4885SLC40A1 3111/4885PKLR 2009/4885 |
| US-20120041207-A1 | Compound | NR4A1, GPR6, PRMT6 | HSD11B1 331/4885SLC40A1 3111/4885PKLR 2009/4885 |
| US-20040143124-A1 | Compound | NR4A1, CBR1, NR2C2 | HSD11B1 192/4885SLC40A1 2902/4885PKLR 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.