Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL8624951 | 1.00 | MAPT (0.48) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| Potassium Ion SCHEMBL29349588 | 1.00 | MAPT (0.48) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| SCHEMBL9301307 | 0.97 | MAPT (0.48) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| SCHEMBL11607920 | 0.97 | MAPT (0.48) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| SCHEMBL9301284 | 0.89 | MAPT (0.50) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| SCHEMBL28088781 | 0.89 | MAPT (0.50) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| SCHEMBL8680909 | 0.89 | MAPT (0.50) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| Potassium Ion SCHEMBL6129087 | 0.88 | CA12 (0.43) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| Potassium Ion SCHEMBL4826211 | 0.88 | CA12 (0.43) | MAPTMDM4LMNAMDM2SMN1; SMN2 | |
| Potassium Ion SCHEMBL31198116 | 0.88 | CA12 (0.43) | MAPTMDM4LMNAMDM2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439096-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1991-07-31 | — | — | EP | claimed |
| EP-0523585-B1 | Improvements in or relating to beta lactam production | SANDOZ AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| EP-0439096-B1 | Improvements in or relating to beta lactam production | BIOCHEMIE GMBH (AT) | 2003-12-17 | — | — | EP | disclosed |
| EP-0793666-B1 | SILYLATION PROCESS | BIOCHEMIE GMBH (AT) | 2002-04-24 | — | — | EP | disclosed |
| EP-0976755-A1 | Improvements in or relating to beta lactam production | BIOCHEMIE Gesellschaft m.b.H. (AT) | 2000-02-02 | — | — | EP | disclosed |
| US-5998610-A | SILYLATION OF 7-AMINODEACETOXYCEPHALOSPORANIC ACID IN PRESENCE OF AN ESTER SOLVENT | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1999-12-07 | — | — | US | disclosed |
| US-5908929-A | Process for the manufacture of the antibiotic 7-(D-α-amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid (cephalexin) and pharmaceutically acceptable salts thereof | VITARA CHEMICALS LIMITED (IN) | 1999-06-01 | — | — | US | disclosed |
| US-5840885-A | REACTING WITH A MIXED CARBOXYLIC ANHYDRIDE IN A HALOGEN-FREE SOLVENT | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1998-11-24 | — | — | US | disclosed |
| US-5719276-A | — | — | 1998-02-17 | — | — | US | disclosed |
| US-5608055-A | Beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1997-03-04 | — | — | US | disclosed |
| EP-0523585-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE Gesellschaft m.b.H. (AT) | 1993-01-20 | — | — | EP | disclosed |
| EP-0439096-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1991-07-31 | — | — | EP | disclosed |
| EP-0127541-B1 | SALTS OF AMINO-BETA-LACTAMIC ACIDS AND PROCESS FOR THE PREPARATION THEREOF | GEMA S.A. (ES) | 1990-08-01 | — | — | EP | disclosed |
| US-4659814-A | Salts of amino-beta-lactamic acids and process for the preparation thereof | GEMA, S.A. (ES) | 1987-04-21 | — | — | US | disclosed |
| EP-0127541-A2 | Salts of amino-beta-lactamic acids and process for the preparation thereof | GEMA S.A. (ES) | 1984-12-05 | — | — | EP | disclosed |
| US-4072710-A | FROM SILYL ESTER AND THIONYL CHLORIDE | PALOMO COLL A L | 1978-02-07 | — | — | US | disclosed |