Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | MIF | P14174 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL6129087 | 1.00 | CA12 (0.43) | CA12CA1CA2CA9CA7 | |
| Potassium Ion SCHEMBL31198116 | 1.00 | CA12 (0.43) | CA12CA1CA2CA9CA7 | |
| SCHEMBL9302196 | 0.97 | CA12 (0.43) | CA12CA1CA2CA9CA7 | |
| Potassium Ion SCHEMBL29349588 | 0.88 | MAPT (0.48) | MAPTLMNAMDM2MDM4KMT2A | |
| SCHEMBL3987755 | 0.88 | FOLH1 (0.46) | CA12CA1CA2CA9CA7 | |
| SCHEMBL3987754 | 0.88 | FOLH1 (0.46) | CA12CA1CA2CA9CA7 | |
| Potassium Ion SCHEMBL8624951 | 0.88 | MAPT (0.48) | MAPTLMNAMDM2MDM4KMT2A | |
| Potassium Ion SCHEMBL6155599 | 0.88 | MAPT (0.48) | MAPTLMNAMDM2MDM4KMT2A | |
| Potassium Ion SCHEMBL4816016 | 0.87 | CA12 (0.40) | CA12CA1CA2CA9CA7 | |
| Potassium Ion SCHEMBL30367664 | 0.87 | CA12 (0.40) | CA12CA1CA2CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230097-B2 | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2007-06-12 | — | — | US | claimed |
| US-20050113570-A1 | Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2005-05-26 | — | — | US | claimed |
| EP-0439096-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1991-07-31 | — | — | EP | claimed |
| US-7427692-B2 | Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (US) | 2008-09-23 | — | — | US | disclosed |
| US-7355041-B2 | Intermediates in cefprozil production | SANDOZ GMBH (AU) | 2008-04-08 | — | — | US | disclosed |
| US-7230097-B2 | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2007-06-12 | — | — | US | disclosed |
| US-20060149096-A1 | Process for preparation of 7-[a-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2006-07-06 | — | — | US | disclosed |
| US-20050113570-A1 | Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2005-05-26 | — | — | US | disclosed |
| EP-0523585-B1 | Improvements in or relating to beta lactam production | SANDOZ AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-20040192909-A1 | Intermediates in cephalosporin production | SANDOZ GMBH (AT) | 2004-09-30 | — | — | US | disclosed |
| EP-1414827-A2 | INTERMEDIATES IN CEPHALOSPORIN PRODUCTION | SANDOZ GMBH (AT) | 2004-05-06 | — | — | EP | disclosed |
| US-5338868-A | Reacting glycine derivative with trifluoro methane sulfonic acid derivative at low temperature | CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1994-08-16 | — | — | US | disclosed |
| EP-0523585-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE Gesellschaft m.b.H. (AT) | 1993-01-20 | — | — | EP | disclosed |
| EP-0439096-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1991-07-31 | — | — | EP | disclosed |
| EP-0127541-B1 | SALTS OF AMINO-BETA-LACTAMIC ACIDS AND PROCESS FOR THE PREPARATION THEREOF | GEMA S.A. (ES) | 1990-08-01 | — | — | EP | disclosed |
| US-4659814-A | Salts of amino-beta-lactamic acids and process for the preparation thereof | GEMA, S.A. (ES) | 1987-04-21 | — | — | US | disclosed |
| EP-0127541-A2 | Salts of amino-beta-lactamic acids and process for the preparation thereof | GEMA S.A. (ES) | 1984-12-05 | — | — | EP | disclosed |
| US-4358588-A | 7-/D-ALPHA-AMINO/P-HYDROXYPHENYL/ACETAMIDO-3- CEPHEM-4-CARBOXYLIC ACID DERIVATIVES; EFFICIENCY | GIST-BROCADES N.V. (NL) | 1982-11-09 | — | — | US | disclosed |
| EP-0001133-A1 | Process for the preparation of 6- D-alpha-amino-(p-hydroxyphenyl)-acetamido penicillanic acid | GIST-BROCADES N.V. (NL) | 1979-03-21 | — | — | EP | disclosed |
| US-4128547-A | TERTIARY AMINE CATALYST | GIST-BROCADES N.V. (NL) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113570-A1 | Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | IGLV6-57, APC, HBZ | AGTR1 2071/4885CA12 1149/4885CA1 1075/4885 |
| US-20060149096-A1 | Process for preparation of 7-[a-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | IGLV6-57, APC, IL2 | AGTR1 1901/4885CA12 1074/4885CA1 1217/4885 |
| US-20040192909-A1 | Intermediates in cephalosporin production | MRPL21, PEPD, CUTA | AGTR1 1835/4885CA12 1598/4885CA1 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.