Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.64 |
| ▸ | CA2 | P00918 | 6/20 | 0.64 |
| ▸ | CA9 | Q16790 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156056 | 0.80 | SLC6A5 (0.47) | — | |
| SCHEMBL11880873 | 0.79 | CA1 (0.74) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL28574459 | 0.78 | ALDH1A1 (0.73) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL29609330 | 0.78 | KMT2A (0.73) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL30165930 | 0.76 | CA2 (0.70) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL28573216 | 0.76 | CA2 (0.70) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL6264342 | 0.76 | HPGD (0.49) | ALDH1A1LMNAKMT2AGAAMEN1 | |
| SCHEMBL29385160 | 0.75 | ALDH1A1 (0.79) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL28568182 | 0.75 | ALDH1A1 (0.79) | CA1CA2CA9ALDH1A1LMNA | |
| SCHEMBL6046379 | 0.75 | MEN1 (0.90) | CA1CA2CA9CA12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501813-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091232-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | WO | disclosed |