Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SHMT2 | P34897 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220907 | 0.82 | ALDH1A1 (0.70) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL27835642 | 0.82 | MAPT (0.72) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL9218073 | 0.79 | MAPT (0.65) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL617400 | 0.79 | KEAP1 (0.69) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL20764179 | 0.78 | MAPT (0.64) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL10756678 | 0.78 | MAPT (0.78) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL9215562 | 0.77 | MAPT (0.62) | MAPTALDH1A1HPGDSHMT2LMNA | |
| SCHEMBL9213780 | 0.77 | MAPT (0.62) | MAPTALDH1A1HPGDSHMT2LMNA | |
| SCHEMBL1416024 | 0.76 | MEN1 (0.65) | MAPTALDH1A1HPGDSHMT2MEN1 | |
| SCHEMBL2017456 | 0.75 | MAPT (0.75) | MAPTALDH1A1HPGDSHMT2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016085990-A1 | COMPOSITIONS AND METHODS RELATING TO INHIBITING SERINE HYRDOXYMETHYLTRANSFERASE 2 ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-06-02 | — | — | WO | disclosed |
| US-20120041207-A1 | Compound | STERIX LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20110009448-A1 | Compound | STERIX LIMITED | 2011-01-13 | — | — | US | disclosed |
| US-7309715-B2 | Compound | STERIX LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| EP-1556040-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 | Sterix Limited (GB) | 2005-07-27 | — | — | EP | disclosed |
| US-20040143124-A1 | Compound | STERIX LIMITED (GB) | 2004-07-22 | — | — | US | disclosed |
| WO-2004037251-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 | STERIX LIMITED (GB) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009448-A1 | Compound | NR4A1, GPR6, PRMT6 | MAPT 4794/4885ALDH1A1 1319/4885HPGD 2152/4885 |
| US-20120041207-A1 | Compound | NR4A1, GPR6, PRMT6 | MAPT 4794/4885ALDH1A1 1319/4885HPGD 2152/4885 |
| US-20040143124-A1 | Compound | NR4A1, CBR1, NR2C2 | MAPT 4691/4885ALDH1A1 553/4885HPGD 2337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.