Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 5/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153703 | 1.00 | IMPDH2 (0.45) | IMPDH2ALDH1A1IMPDH1PSEN1PSEN2 | |
| SCHEMBL6154051 | 0.86 | IMPDH2 (0.41) | IMPDH2ALDH1A1IMPDH1ARKDM4E | |
| SCHEMBL6154049 | 0.86 | IMPDH2 (0.41) | IMPDH2ALDH1A1IMPDH1ARKDM4E | |
| SCHEMBL6156906 | 0.79 | IMPDH2 (0.47) | IMPDH2ALDH1A1IMPDH1ARKDM4E | |
| SCHEMBL6153700 | 0.79 | IMPDH2 (0.47) | IMPDH2ALDH1A1IMPDH1ARKDM4E | |
| SCHEMBL6154460 | 0.77 | SUV39H2 (0.47) | IMPDH2ALDH1A1IMPDH1KDM4EGAA | |
| SCHEMBL6154416 | 0.77 | SUV39H2 (0.47) | IMPDH2ALDH1A1IMPDH1KDM4EGAA | |
| SCHEMBL6154412 | 0.77 | SUV39H2 (0.47) | IMPDH2ALDH1A1IMPDH1KDM4EGAA | |
| SCHEMBL27236967 | 0.70 | HDAC8 (0.46) | ALDH1A1ARGAADPP4 | |
| SCHEMBL6153885 | 0.70 | MELK (0.38) | ALDH1A1ARKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | IMPDH2 2157/4885ALDH1A1 2454/4885IMPDH1 1884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.