Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160794 | 0.88 | KMT2A (0.51) | KMT2AMEN1TSHRALDH1A1HPGD | |
| SCHEMBL6158841 | 0.79 | KMT2A (0.61) | KMT2AMEN1TSHRALDH1A1HPGD | |
| SCHEMBL27561838 | 0.74 | KMT2A (0.41) | KMT2AMEN1TSHRHPGDCPA1 | |
| SCHEMBL8670529 | 0.73 | ALDH1A1 (0.58) | KMT2AMEN1TSHRALDH1A1HPGD | |
| SCHEMBL6045130 | 0.73 | KMT2A (0.79) | KMT2AMEN1TSHRALDH1A1HPGD | |
| SCHEMBL14519817 | 0.72 | POLB (0.54) | KMT2AMEN1TSHRALDH1A1HPGD | |
| Naphthalene SCHEMBL7417075 | 0.72 | CASP3 (0.51) | KMT2AALDH1A1HPGD | |
| SCHEMBL6158716 | 0.72 | CASP1 (0.60) | KMT2AALDH1A1HPGDPOLBANPEP | |
| SCHEMBL5907625 | 0.72 | KMT2A (0.63) | KMT2AMEN1TSHRALDH1A1HPGD | |
| SCHEMBL6425753 | 0.71 | HDAC3 (0.60) | KMT2AMEN1ALDH1A1HPGDTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| CN-1308542-A | Succinamide inhibitors of interleukin-1 beta converting enzyme | WARNET LAMBERT CO (US) | 2001-08-15 | — | — | CN | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |