Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159601 | 0.85 | ALDH1A1 (0.36) | — | |
| SCHEMBL6160221 | 0.84 | KMT2A (0.33) | — | |
| SCHEMBL6158571 | 0.83 | PPIA (0.35) | HSD11B1PPIANR1H2NR1H3 | |
| SCHEMBL8913129 | 0.82 | INMT (0.33) | — | |
| SCHEMBL16757131 | 0.80 | PPIA (0.41) | HSD11B1PPIANR1H2NR1H3 | |
| SCHEMBL6160923 | 0.80 | MAPT (0.32) | BRD4 | |
| SCHEMBL8912293 | 0.80 | FPR3 (0.35) | — | |
| SCHEMBL6159537 | 0.79 | PPIA (0.33) | PPIA | |
| SCHEMBL8912155 | 0.76 | TSHR (0.34) | — | |
| SCHEMBL6160365 | 0.74 | MAPT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739891-B1 | Substituted heterocycles | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | EP | claimed |
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | claimed |
| EP-0739891-B1 | Substituted heterocycles | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | EP | disclosed |
| US-6355695-B1 | ANTIHISTAMINES; ASTHMA THERAPY | ZENECA LIMITED (SE) | 2002-03-12 | — | — | US | disclosed |
| US-6235757-B1 | ANTIHISTAMINES | ZENECA LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-6051580-A | Substituted heterocycles | ZENECA LIMITED | 2000-04-18 | — | — | US | disclosed |
| US-5889024-A | Substituted heterocycles | ZENECA LIMITED (GB) | 1999-03-30 | — | — | US | disclosed |
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |