Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.39 |
| ▸ | PADI3 | Q9ULW8 | 2/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156971 | 0.77 | MAPK8 (0.43) | HPGDL3MBTL1LMNAGAAKDM4E | |
| SCHEMBL6264342 | 0.75 | HPGD (0.49) | HPGDL3MBTL1LMNAGAAKDM4E | |
| SCHEMBL6346326 | 0.72 | MME (0.43) | TDP1 | |
| SCHEMBL3190128 | 0.70 | PADI1 (0.55) | PADI1PADI3PADI4ALDH1A1CA12 | |
| SCHEMBL5569820 | 0.70 | PADI1 (0.55) | PADI1PADI3PADI4ALDH1A1CA12 | |
| SCHEMBL6266482 | 0.68 | KMT2A (0.43) | HPGDL3MBTL1LMNAGAATDP1 | |
| SCHEMBL5144034 | 0.68 | HDAC3 (0.50) | HPGDLMNAKDM4EALDH1A1CHRNB2 | |
| SCHEMBL12984129 | 0.68 | CA2 (0.46) | HPGDL3MBTL1LMNAGAAKDM4E | |
| SCHEMBL6158888 | 0.67 | KCNA5 (0.38) | KCNA5HPGDL3MBTL1LMNAGAA | |
| SCHEMBL1360852 | 0.67 | IL1RN (0.39) | IL1RNERAP2ERAP1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501813-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091232-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | WO | disclosed |