Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9190506 | 0.87 | ALDH1A1 (0.55) | PTAFRALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL6160639 | 0.85 | PTAFR (0.59) | PTAFRALDH1A1KDM4ECHRM2L3MBTL1 | |
| SCHEMBL16606319 | 0.81 | CHRM2 (0.68) | CHRM2TDP1L3MBTL1NOS1 | |
| SCHEMBL6159739 | 0.80 | CHRM2 (0.56) | PTAFRKMT2ACHRM2TDP1 | |
| SCHEMBL6165459 | 0.80 | KMT2A (0.54) | PTAFRALDH1A1GAAKMT2APOLB | |
| SCHEMBL6158945 | 0.77 | SIGMAR1 (0.68) | CHRM2TDP1L3MBTL1 | |
| SCHEMBL6160313 | 0.74 | SIGMAR1 (0.68) | PTAFRCHRM2TDP1L3MBTL1 | |
| SCHEMBL6157737 | 0.74 | SIGMAR1 (0.70) | CHRM2TDP1L3MBTL1 | |
| SCHEMBL10730509 | 0.74 | CYP2A6 (0.74) | CHRM2TDP1L3MBTL1NOS1 | |
| SCHEMBL6161198 | 0.74 | SIGMAR1 (0.68) | PTAFRCHRM2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129070-A4 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1129070-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6228872-B1 | PEPTIDE-PROLYL ISOMERASE AND ROTAMASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-08 | — | — | US | disclosed |
| WO-2000027811-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |