Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.56 |
| ▸ | PTAFR | P25105 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28177088 | 0.87 | HTR1A (0.67) | CHRM2PTAFRHTR1ADRD2CHRM1 | |
| SCHEMBL6165459 | 0.86 | KMT2A (0.54) | CHRM2PTAFRPTGDRACP1MEN1 | |
| SCHEMBL16606319 | 0.82 | CHRM2 (0.68) | CHRM2TDP1 | |
| SCHEMBL5099393 | 0.81 | TAAR1 (0.68) | CHRM2MTNR1AMTNR1BCHRM1CHRM3 | |
| SCHEMBL6160639 | 0.81 | PTAFR (0.59) | CHRM2PTAFR | |
| SCHEMBL7985841 | 0.80 | SIGMAR1 (0.64) | CHRM2DRD2MTNR1AMTNR1BCHRM1 | |
| SCHEMBL5678830 | 0.80 | CHRM2 (0.66) | CHRM2MTNR1AMTNR1BCHRM1CHRM3 | |
| SCHEMBL6158967 | 0.80 | PTAFR (0.52) | CHRM2PTAFRKMT2ATDP1 | |
| SCHEMBL10470624 | 0.80 | PTAFR (0.64) | PTAFRMEN1KMT2ATDP1 | |
| SCHEMBL6158945 | 0.78 | SIGMAR1 (0.68) | CHRM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129070-A4 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1129070-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027811-A1 | NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |