Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.55 |
| ▸ | DRD4 | P21917 | 11/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13898517 | 0.76 | CCR5 (0.60) | DRD2DRD4CCR5 | |
| SCHEMBL3892595 | 0.76 | CCR5 (0.60) | DRD2DRD4CCR5 | |
| SCHEMBL6159534 | 0.76 | SLC6A2 (0.53) | DRD2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6160574 | 0.76 | SLC6A2 (0.53) | DRD2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6159481 | 0.75 | OPRL1 (0.44) | DRD4OPRM1OPRL1KCNH2 | |
| SCHEMBL6158951 | 0.75 | MEN1 (0.51) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL6159875 | 0.75 | HTR2A (0.54) | DRD2DRD4SLC6A4SLC6A3OPRM1 | |
| SCHEMBL6162587 | 0.75 | KDM4E (0.47) | OPRM1OPRL1KCNH2 | |
| SCHEMBL6158959 | 0.75 | MEN1 (0.51) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL8211043 | 0.75 | SLC6A2 (0.57) | DRD2DRD4SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |