Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 4/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159547 | 0.84 | PARK7 (0.36) | OPRL1OPRM1KCNH2PARK7CACNA1G | |
| SCHEMBL6162560 | 0.80 | DRD2 (0.45) | HSD11B1PARK7DRD4 | |
| SCHEMBL6158959 | 0.76 | MEN1 (0.51) | OPRL1OPRM1KCNH2CACNA1G | |
| SCHEMBL6162587 | 0.76 | KDM4E (0.47) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6158951 | 0.76 | MEN1 (0.51) | OPRL1OPRM1KCNH2CACNA1G | |
| SCHEMBL6159875 | 0.76 | HTR2A (0.54) | OPRL1OPRM1KCNH2DRD4 | |
| SCHEMBL8211064 | 0.76 | CACNA1G (0.39) | CACNA1G | |
| SCHEMBL6160819 | 0.75 | DRD2 (0.55) | OPRL1OPRM1KCNH2DRD4 | |
| SCHEMBL13898484 | 0.75 | SIGMAR1 (0.47) | — | |
| SCHEMBL8220653 | 0.74 | SLC18A3 (0.43) | TACR1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |