Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160585 | 0.87 | GRIN2B (0.52) | GRIN2BKMT2A | |
| SCHEMBL6159469 | 0.80 | ALDH1A1 (0.51) | HTR2AHTR2CKCNH2GRIN2BDRD2 | |
| SCHEMBL6162587 | 0.78 | KDM4E (0.47) | KCNH2GRIN2BKMT2AOPRM1OPRL1 | |
| SCHEMBL6158951 | 0.76 | MEN1 (0.51) | HTR2AHTR2CKCNH2DRD2SLC6A4 | |
| SCHEMBL6159481 | 0.76 | OPRL1 (0.44) | KCNH2DRD4OPRM1OPRL1 | |
| SCHEMBL6158959 | 0.76 | MEN1 (0.51) | HTR2AHTR2CKCNH2DRD2SLC6A4 | |
| SCHEMBL6160819 | 0.75 | DRD2 (0.55) | HTR2CKCNH2DRD2DRD4SLC6A4 | |
| SCHEMBL3890408 | 0.75 | SIGMAR1 (0.62) | HTR2AHTR2CKCNH2GRIN2BDRD2 | |
| SCHEMBL3436615 | 0.74 | OPRL1 (0.50) | KCNH2DRD4OPRM1OPRL1 | |
| SCHEMBL8216077 | 0.74 | DRD2 (0.59) | HTR2AHTR2CKCNH2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |