Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161715 | 0.79 | SLC6A2 (0.46) | HTR1ASLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL7723133 | 0.77 | HTR1A (0.50) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL6159989 | 0.75 | DRD2 (0.40) | HTR1AADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL11508466 | 0.73 | SLC6A2 (0.72) | HTR1ASLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL8222205 | 0.73 | MAPK1 (0.43) | HTR1ASLC6A2SLC6A3KMT2AALDH1A1 | |
| SCHEMBL13898515 | 0.72 | OPRL1 (0.51) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL11498523 | 0.72 | SLC6A2 (0.70) | HTR1ASLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL6161140 | 0.71 | ALDH1A1 (0.59) | HTR1ASLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL6161143 | 0.71 | ALDH1A1 (0.59) | HTR1ASLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL19562130 | 0.70 | SLC6A4 (0.52) | SLC6A2SLC6A4ADRA1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |