Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 5/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996205 | 0.92 | PSMB5 (0.43) | SIRT2PPARDPPARAALDH1A1TP53 | |
| SCHEMBL3996571 | 0.83 | PSMB5 (0.43) | SIRT2PPARDPPARATP53MAPT | |
| SCHEMBL4962776 | 0.82 | TRPM8 (0.54) | PPARGPPARDPPARAALDH1A1TP53 | |
| SCHEMBL6160658 | 0.81 | SIRT2 (0.43) | SLC2A1SIRT2PPARGPPARDPPARA | |
| SCHEMBL4961643 | 0.75 | TRPM8 (0.63) | ALDH1A1ABCB1LPAR1 | |
| SCHEMBL4961943 | 0.74 | TRPM8 (0.53) | ALDH1A1TP53MAPTMEN1KMT2A | |
| SCHEMBL6160051 | 0.73 | SIRT2 (0.44) | SLC2A1SIRT2PPARDPPARAMAPT | |
| SCHEMBL4962720 | 0.73 | TRPM8 (0.57) | ALDH1A1TP53MAPTLPAR1LPAR5 | |
| SCHEMBL3507026 | 0.72 | SIRT2 (0.59) | SIRT2PPARGPPARDPPARAALDH1A1 | |
| SCHEMBL6160660 | 0.72 | ENPP2 (0.42) | SIRT2PPARGPPARDPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517680-A1 | BENZOIC ACID DERIVATIVES AS MODULATORS OF PPAR ALPHA AND GAMMA | Astrazeneca AB (SE) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000295-A1 | BENZOIC ACID DERIVATIVES AS MODULATORS OF PPAR ALPHA AND GAMMA | ASTRAZENECA AB (SE) | 2003-12-31 | — | — | WO | claimed |