Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160051 | 0.92 | SIRT2 (0.44) | SIRT2PPARAPARP1PPARDMRGPRX4 | |
| SCHEMBL6160660 | 0.91 | ENPP2 (0.42) | SIRT2PPARAPPARGALDH1A1PPARD | |
| SCHEMBL6160055 | 0.83 | SIRT2 (0.41) | SIRT2PPARAPPARGALDH1A1PPARD | |
| SCHEMBL6161238 | 0.81 | SLC2A1 (0.44) | SIRT2PPARAPPARGPARP1ALDH1A1 | |
| SCHEMBL3507026 | 0.73 | SIRT2 (0.59) | SIRT2PPARAPPARGALDH1A1PPARD | |
| SCHEMBL3996205 | 0.72 | PSMB5 (0.43) | SIRT2PPARAALDH1A1PPARDENPP2 | |
| SCHEMBL6160652 | 0.71 | ENPP2 (0.41) | SIRT2PPARAPPARGALDH1A1PPARD | |
| SCHEMBL6161235 | 0.71 | ABCC8 (0.43) | SIRT2PPARAPPARDENPP2 | |
| SCHEMBL3507509 | 0.69 | SIRT2 (0.53) | SIRT2PPARAPPARGALDH1A1PTGES | |
| SCHEMBL4962776 | 0.69 | TRPM8 (0.54) | PPARAPPARGALDH1A1PPARDPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517680-A1 | BENZOIC ACID DERIVATIVES AS MODULATORS OF PPAR ALPHA AND GAMMA | Astrazeneca AB (SE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000295-A1 | BENZOIC ACID DERIVATIVES AS MODULATORS OF PPAR ALPHA AND GAMMA | ASTRAZENECA AB (SE) | 2003-12-31 | — | — | WO | disclosed |