SCHEMBL6162163

SCHEMBL6162163

CC(C)Cc1nn(-c2ccccc2)c2c1C(=O)CC(C(C)C)C2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.41
CACNA1H O95180 2/20 0.37
BUB1 O43683 2/20 0.35
CSNK2A2 P19784 4/20 0.33
CSNK2B P67870 4/20 0.33
CSNK2A1 P68400 4/20 0.33
ABCG2 Q9UNQ0 4/20 0.33
BRD4 O60885 1/20 0.33
CACNA1G O43497 1/20 0.33
KCNH2 Q12809 1/20 0.33
SLC5A1 P13866 2/20 0.33
KHK P50053 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CCNA2 P20248 1/20 0.33
CDK2 P24941 1/20 0.33
HIF1A Q16665 1/20 0.33
CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6770489 0.88 DHODH (0.35) DHODHBUB1
SCHEMBL6772419 0.88 SRC (0.39) DHODHMEN1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL6165346 0.87 ALDH1A1 (0.40) DHODHBUB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL6167945 0.87 DHODH (0.37) DHODHCACNA1HBUB1CSNK2A2CSNK2B
SCHEMBL6167949 0.87 ABCG2 (0.44) CACNA1HBUB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL6772551 0.86 DHODH (0.37) DHODHMEN1ALDH1A1KMT2ASMN1; SMN2
SCHEMBL6168301 0.84 SMN1; SMN2 (0.43) DHODHBUB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL6167296 0.83 HIF1A (0.47) DHODHBRD4MEN1ALDH1A1KMT2A
SCHEMBL6164978 0.82 DHODH (0.41) DHODHBUB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL6164547 0.81 DHODH (0.43) DHODHBUB1BRD4MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177185-B1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-04-20 EP disclosed
US-6716856-B1 CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY PHARMACIA & TUBJOHN SPA (IT) 2004-04-06 US disclosed
EP-1177185-A1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 2002-02-06 EP disclosed
WO-2000069846-A1 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2000-11-23 WO disclosed