Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767785 | 0.89 | L3MBTL1 (0.39) | DHODHPDE4BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6769804 | 0.88 | PPARA (0.38) | DHODHBUB1PDE4B | |
| SCHEMBL6767259 | 0.87 | SRC (0.40) | DHODHALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6167296 | 0.86 | HIF1A (0.47) | DHODHALDH1A1BRD4HIF1ASMN1; SMN2 | |
| SCHEMBL6164455 | 0.86 | ABCG2 (0.47) | BUB1PDE4BALDH1A1GAAHIF1A | |
| SCHEMBL6777339 | 0.85 | CASP1 (0.39) | DHODHALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6168419 | 0.84 | DHODH (0.42) | DHODHBUB1ALDH1A1GAABRD4 | |
| SCHEMBL6163901 | 0.83 | SMN1; SMN2 (0.46) | DHODHBUB1ALDH1A1SMN1; SMN2CCNA2 | |
| SCHEMBL6164978 | 0.82 | DHODH (0.41) | DHODHBUB1ALDH1A1GAABRD4 | |
| SCHEMBL6162163 | 0.81 | DHODH (0.41) | DHODHBUB1ALDH1A1BRD4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |