Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777392 | 0.88 | DHODH (0.36) | DHODHBUB1 | |
| SCHEMBL7490727 | 0.88 | L3MBTL1 (0.36) | DHODHKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6770539 | 0.88 | SRC (0.39) | DHODHMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL6766674 | 0.86 | RIPK2 (0.46) | DHODHMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6164779 | 0.84 | SMN1; SMN2 (0.44) | DHODHBUB1ALDH1A1SMN1; SMN2CCNA2 | |
| SCHEMBL6164677 | 0.84 | ABCG2 (0.41) | MEN1KMT2AHSP90AA1ATMBUB1 | |
| SCHEMBL6167296 | 0.84 | HIF1A (0.47) | DHODHMEN1KMT2ABRD4ALDH1A1 | |
| SCHEMBL6164547 | 0.82 | DHODH (0.43) | DHODHMEN1KMT2ABUB1BRD4 | |
| SCHEMBL6162163 | 0.82 | DHODH (0.41) | DHODHMEN1KMT2ABUB1BRD4 | |
| SCHEMBL6168419 | 0.81 | DHODH (0.42) | DHODHMEN1KMT2ABUB1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |