Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | HTR1A | P08908 | 6/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 7/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11784970 | 0.84 | HTR6 (0.65) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL13944390 | 0.78 | HTR6 (0.51) | HTR6DRD2HTR1AHTR7 | |
| SCHEMBL8450188 | 0.77 | HTR7 (0.44) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL10366044 | 0.76 | KCNH2 (0.53) | HTR6DRD2HTR7 | |
| SCHEMBL6042752 | 0.76 | DRD2 (0.63) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL9462570 | 0.74 | HTR7 (0.43) | HTR6DRD2HTR7 | |
| SCHEMBL2395932 | 0.74 | DRD4 (0.67) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL28680519 | 0.74 | HTR6 (0.56) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL7543848 | 0.72 | HTR1A (1.00) | HTR6DRD2HTR1AHTR2AHTT | |
| SCHEMBL6707943 | 0.72 | DRD2 (0.59) | HTR6DRD2HTR1AHTR2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |