SCHEMBL6162718

SCHEMBL6162718

NC(=O)C1SCCN1C(=O)[CH]Cc1ccccc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFD P00746 4/20 0.40
DPP4 P27487 2/20 0.39
FAP Q12884 1/20 0.39
DPP8 Q6V1X1 1/20 0.39
DPP9 Q86TI2 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.37
SIRT1 Q96EB6 1/20 0.37
SCN3A Q9NY46 6/20 0.37
DPP7 Q9UHL4 1/20 0.36
BRD4 O60885 1/20 0.35
KCNH2 Q12809 5/20 0.35
SCN1A P35498 1/20 0.35
SCN4A P35499 1/20 0.35
SCN7A Q01118 1/20 0.35
SCN5A Q14524 1/20 0.35
SCN9A Q15858 1/20 0.35
SCN2A Q99250 1/20 0.35
SCN8A Q9UQD0 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6167323 0.86 LMNA (0.44) CFDSIRT2SIRT1ALDH1A1CYP1A2
SCHEMBL6163040 0.83 RIPK1 (0.36) CFDDPP4DPP8DPP9SIRT1
SCHEMBL6052882 0.75 SCN3A (0.41) DPP4FAPDPP8DPP9SIRT2
SCHEMBL6161261 0.74 CFD (0.44) CFDALDH1A1SIGMAR1
SCHEMBL6162964 0.72 DPP7 (0.43) CFDDPP4FAPDPP8DPP9
SCHEMBL8414762 0.70 RAB9A (0.42) ALDH1A1CYP2C19
SCHEMBL2936418 0.70 ALDH1A1 (0.50) SIRT2SIRT1SCN3AKCNH2ALDH1A1
SCHEMBL6350305 0.67 ACE (0.37) CFDDPP4FAPDPP8DPP9
SCHEMBL3137610 0.63 CNR2 (0.39) DPP4SIGMAR1CYP2C19
SCHEMBL6162264 0.63 DPP4 (0.38) DPP4FAPDPP8DPP9DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1134213-B1 Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides PFIZER (US) 2005-11-02 EP disclosed
EP-0832065-B1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER (US) 2001-10-10 EP disclosed
EP-1134213-A2 Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides PFIZER INC. (US) 2001-09-19 EP disclosed
US-6277877-B1 GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS PFIZER, INC. 2001-08-21 US disclosed
US-6107329-A HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS PFIZER, INC. (US) 2000-08-22 US disclosed
WO-1996039384-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER, INC. (US) 1996-12-12 WO disclosed