Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166123 | 0.83 | ALPL (0.43) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6162505 | 0.82 | ALPL (0.67) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6165525 | 0.81 | HTT (0.61) | KMT2AHTTHDAC1HDAC6OPRM1 | |
| SCHEMBL6164099 | 0.78 | HTT (0.66) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6165665 | 0.77 | ALPL (0.39) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6164100 | 0.77 | HDAC1 (0.45) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6164718 | 0.77 | HTT (0.41) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6164113 | 0.77 | OPRM1 (0.49) | ALPLALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6163497 | 0.76 | HTT (0.40) | ALPLALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL6164449 | 0.73 | HTT (0.38) | ALPLALDH1A1NPSR1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |