SCHEMBL6162977

SCHEMBL6162977

COc1cc(C(=O)NC2CC2)c(Cl)cc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.56
ALDH1A1 P00352 1/20 0.56
HTR4 Q13639 6/20 0.52
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
TAS1R2 Q8TE23 1/20 0.50
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
MAPT P10636 1/20 0.49
KMT2A Q03164 1/20 0.49
RAB9A P51151 3/20 0.49
NPC1 O15118 2/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA3 P07451 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8040249 0.84 PYGL (0.47) HPGDALDH1A1HTR4TAS1R3TAS1R1
SCHEMBL2663963 0.79 KDM4E (0.51) ALDH1A1KDM4EMAPTRAB9ANPC1
SCHEMBL8028305 0.78 ALDH1A1 (0.51) ALDH1A1MEN1MAPTKMT2ARAB9A
SCHEMBL8044925 0.78 ALDH1A1 (0.51) ALDH1A1MEN1MAPTKMT2ARAB9A
SCHEMBL13696478 0.77 ALDH1A1 (0.59) HPGDALDH1A1HTR4TAS1R3TAS1R1
SCHEMBL20630963 0.77 HTR4 (0.58) HPGDALDH1A1HTR4DRD4
SCHEMBL8032092 0.77 ALDH1A1 (0.44) HPGDALDH1A1HTR4TAS1R3TAS1R1
SCHEMBL15650737 0.76 HTR4 (0.83) HTR4DRD4
SCHEMBL3548445 0.76 HTR4 (0.59) HTR4DRD4
SCHEMBL22490276 0.75 HPGD (0.66) HPGDALDH1A1TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0920423-B1 DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS NEUROSEARCH AS (DK) 2005-01-26 EP disclosed
US-6479491-B1 USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA NEUROSEARCH A/S (DK) 2002-11-12 US disclosed
US-6207662-B1 USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA NEUROSEARCH A/S (DK) 2001-03-27 US disclosed
EP-0920423-A1 DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 1999-06-09 EP disclosed
WO-1998007710-A1 DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 1998-02-26 WO disclosed