Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772625 | 0.90 | CSNK2A2 (0.34) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6770294 | 0.89 | SRC (0.36) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6167945 | 0.88 | DHODH (0.37) | ABCG2CSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL6772144 | 0.87 | RIPK2 (0.36) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6167949 | 0.87 | ABCG2 (0.44) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6166197 | 0.86 | CCNA2 (0.41) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6163485 | 0.83 | ALDH1A1 (0.38) | ABCG2CSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL6163506 | 0.81 | CCNA2 (0.35) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6164280 | 0.81 | OPRM1 (0.45) | ALDH1A1TSHRHTTLMNAMAPK1 | |
| SCHEMBL6168175 | 0.81 | CSNK2A2 (0.33) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |