Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770636 | 0.90 | RIPK2 (0.35) | RIPK2SLC5A1RAB9ASMN1; SMN2PDE4A | |
| SCHEMBL6770294 | 0.89 | SRC (0.36) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6163003 | 0.87 | ABCG2 (0.40) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6778055 | 0.85 | SRC (0.43) | RIPK2ABCG2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6771525 | 0.83 | OPRM1 (0.50) | SRC | |
| SCHEMBL6772625 | 0.82 | CSNK2A2 (0.34) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6766537 | 0.81 | ALDH1A1 (0.41) | ABCG2HPGDSLC5A1RAB9ASMN1; SMN2 | |
| SCHEMBL6766708 | 0.81 | RIPK2 (0.48) | RIPK2HPGDRAB9ASMN1; SMN2SRC | |
| SCHEMBL6775862 | 0.79 | ABCG2 (0.39) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6772063 | 0.79 | OPRM1 (0.48) | RAB9ASMN1; SMN2SRCL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |