Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169697 | 0.90 | ROCK2 (0.40) | ABL1SMN1; SMN2HDAC8CTSLCTSS | |
| SCHEMBL6166677 | 0.87 | PPARG (0.44) | PKMWNT3ARAB9AROCK2ROCK1 | |
| SCHEMBL6168939 | 0.83 | TRPV1 (0.44) | — | |
| SCHEMBL6165543 | 0.83 | MMP12 (0.53) | MMP12LMNAALDH1A1HSD17B10CTSV | |
| SCHEMBL6167389 | 0.83 | ECE1 (0.51) | MMP12PKMWNT3ANAMPTMEN1 | |
| SCHEMBL6160645 | 0.82 | MMP12 (0.50) | MMP12LMNAKMT2ACTSVCTSL | |
| SCHEMBL6160649 | 0.82 | MMP12 (0.50) | MMP12LMNAKMT2ACTSVCTSL | |
| SCHEMBL10438783 | 0.81 | SMN1; SMN2 (0.48) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL6167624 | 0.81 | HDAC2 (0.42) | PKMHDAC8 | |
| SCHEMBL6165947 | 0.78 | TAAR1 (0.49) | KDM4EMEN1USP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | claimed |