Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163974 | 0.90 | MMP12 (0.46) | ROCK2ROCK1HDAC8SMN1; SMN2CTSL | |
| SCHEMBL6166677 | 0.85 | PPARG (0.44) | ROCK2ROCK1PPARG | |
| SCHEMBL10438783 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2 | |
| SCHEMBL6168939 | 0.83 | TRPV1 (0.44) | PPARG | |
| SCHEMBL6169635 | 0.82 | MME (0.50) | — | |
| SCHEMBL6167624 | 0.81 | HDAC2 (0.42) | HDAC8 | |
| SCHEMBL6165947 | 0.80 | TAAR1 (0.49) | SMN1; SMN2 | |
| SCHEMBL6167455 | 0.80 | HPGDS (0.47) | PPARG | |
| SCHEMBL6160300 | 0.80 | TP53 (0.48) | PPARGCTSLCTSS | |
| SCHEMBL6165955 | 0.80 | TP53 (0.48) | PPARGCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | claimed |