Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168606 | 0.91 | OPRL1 (0.52) | OPRL1CHRM3CHRM2DRD2ACHE | |
| SCHEMBL29445321 | 0.91 | OPRL1 (0.52) | OPRL1CHRM3CHRM2DRD2ACHE | |
| SCHEMBL8571871 | 0.90 | CHRM3 (0.54) | OPRL1CHRM3CHRM2DRD2KDM1A | |
| SCHEMBL8570520 | 0.90 | OPRL1 (0.45) | OPRL1CHRM3CHRM2DRD2ACHE | |
| SCHEMBL8564439 | 0.89 | CHRM2 (0.55) | OPRL1CHRM3CHRM2DRD2OPRM1 | |
| SCHEMBL8562694 | 0.88 | KDM1A (0.56) | OPRL1KDM1A | |
| SCHEMBL5100221 | 0.88 | OPRL1 (0.44) | OPRL1CHRM3CHRM2DRD2ACHE | |
| SCHEMBL8569557 | 0.88 | CHRM2 (0.54) | OPRL1CHRM3CHRM2DRD2ACHE | |
| SCHEMBL8562946 | 0.88 | CHRM3 (0.54) | OPRL1CHRM3CHRM2ACHECHRM1 | |
| SCHEMBL8565541 | 0.88 | CHRM2 (0.54) | OPRL1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122253-B1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6645971-B1 | Pollakiuria and urinary incontinence treatment; muscarinic receptor antagonists; anticholinergic, anticonvulsants, antiulcer, and antiasthmatics; Parkinson*s disease | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2003-11-11 | — | — | US | disclosed |
| EP-1122253-A1 | QUINAZOLINONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-08-08 | — | — | EP | disclosed |
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |