Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202241 | 0.89 | PTGS2 (0.40) | PTGS2PTGS1KEAP1 | |
| SCHEMBL6168958 | 0.89 | PTGS2 (0.51) | PTGS2 | |
| SCHEMBL5207362 | 0.87 | PTGS2 (0.39) | PTGS2PTGS1KEAP1 | |
| SCHEMBL5205140 | 0.87 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL5203292 | 0.87 | PTGS2 (0.40) | PTGS2PTGS1CA2CA4 | |
| SCHEMBL5204508 | 0.86 | KEAP1 (0.45) | PTGS2PTGS1KEAP1CA12CA1 | |
| SCHEMBL5201642 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL5204581 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL6167427 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL5205172 | 0.82 | PTGS2 (0.49) | PTGS2PTGS1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1273580-B1 | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | claimed |
| US-6875779-B2 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | PFIZER INC. (US) | 2005-04-05 | — | — | US | claimed |
| US-20040198735-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | SAKYA SUBAS M (US) | 2004-10-07 | — | — | US | claimed |
| US-20030119835-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | PFIZER PRODUCTS, INC. | 2003-06-26 | — | — | US | claimed |
| EP-1273580-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | claimed |
| EP-1273580-B1 | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6875779-B2 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | PFIZER INC. (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040198735-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | SAKYA SUBAS M (US) | 2004-10-07 | — | — | US | disclosed |
| US-6753332-B2 | CYCLOOXYGENASE INHIBITORS | PFIZER, INC. | 2004-06-22 | — | — | US | disclosed |
| US-20030119835-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | PFIZER PRODUCTS, INC. | 2003-06-26 | — | — | US | disclosed |
| EP-1273580-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198735-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | SULT2A1, SULT1A1, SULT1E1 | PTGS2 201/4885PTGS1 51/4885KEAP1 739/4885 |
| US-20030119835-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents | SULT2A1, SULT1A1, SULT1E1 | PTGS2 201/4885PTGS1 51/4885KEAP1 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.