Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166482 | 0.83 | DHODH (0.36) | DHODH | |
| SCHEMBL6164302 | 0.80 | HTT (0.57) | DHODHHTT | |
| SCHEMBL6164331 | 0.79 | DHODH (0.34) | DHODH | |
| SCHEMBL6166292 | 0.78 | HTT (0.36) | HTTBUB1 | |
| SCHEMBL6167296 | 0.76 | HIF1A (0.47) | DHODHBRD4 | |
| SCHEMBL6771481 | 0.74 | OPRM1 (0.43) | DHODHBUB1 | |
| SCHEMBL6770476 | 0.74 | OPRM1 (0.45) | DHODH | |
| SCHEMBL6167189 | 0.73 | DHODH (0.31) | DHODH | |
| SCHEMBL6769819 | 0.71 | OPRM1 (0.43) | DHODH | |
| SCHEMBL6770505 | 0.70 | OPRM1 (0.46) | DHODHHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |